Targeting specific pathways to prevent triple-negative breast cancer in women veterans
Co-Targeting IL-6 and CDK4/6 Pathways as a Novel Approach of Preventive Therapy for Triple-Negative Breast Cancer
This study is testing a new treatment for women veterans with triple-negative breast cancer, aiming to block two specific pathways in the cancer to help improve their chances of recovery and prevent it from spreading.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baltimore VA Medical Center NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10881749 on NIH RePORTER |
What this research studies
This research focuses on developing a new preventive therapy for triple-negative breast cancer (TNBC), which is particularly aggressive and lacks effective treatment options. The study aims to target two specific pathways, Interleukin 6 (IL-6) and cyclin-dependent kinases (CDK)4/6, that are known to be activated in TNBC. By simultaneously inhibiting these pathways, the researchers hope to improve outcomes for women veterans suffering from this type of cancer. The approach is based on previous findings that suggest this dual targeting may enhance the effectiveness of existing treatments and reduce the risk of metastasis.
Who could benefit from this research
Good fit: Ideal candidates for this research are women veterans diagnosed with triple-negative breast cancer.
Not a fit: Patients who do not have triple-negative breast cancer or are not veterans may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a novel preventive therapy that significantly improves survival rates and quality of life for women with triple-negative breast cancer.
How similar studies have performed: While targeting IL-6 and CDK4/6 pathways is a novel approach, previous studies have shown promise in targeting these pathways separately in cancer treatment.
Where this research is happening
Baltimore, United States
- Baltimore VA Medical Center — Baltimore, United States (Active)
Researchers
- Principal investigator: Lin, Jiayuh — Baltimore VA Medical Center
- Study coordinator: Lin, Jiayuh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.