Targeting specific lung cancer stem cells to prevent and treat lung cancer
Lung cancer prevention and treatment by targeting ALDH1 and CD44 expressing putative lung cancer stem cells
This study is looking at how to stop and treat lung cancer by using special drugs that have been changed to work better, and it will test these drugs in mice to see if they can help shrink lung tumors caused by smoking and genetic changes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10689962 on NIH RePORTER |
What this research studies
This research investigates how to prevent and treat lung cancer by focusing on specific stem cells that are believed to contribute to the disease. The approach involves using repurposed drugs, disulfiram and sulfasalazine, which are specially formulated to enhance their effectiveness. The study will test these drugs in mice to see if they can reduce the growth of lung tumors caused by tobacco smoke and genetic mutations. By targeting cancer stem cells, the research aims to find a more effective way to combat lung cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at high risk for lung cancer, particularly those with a history of tobacco use or genetic predispositions.
Not a fit: Patients who do not have lung cancer or are not at risk for developing lung cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the incidence and progression of lung cancer.
How similar studies have performed: Other research has shown promise in targeting cancer stem cells for treatment, suggesting that this approach could be effective.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Kassie, Fekadu — University of Minnesota
- Study coordinator: Kassie, Fekadu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.