Targeting specific liver receptors to improve heart and liver health
Macrophage-specific targeting of LXRs in CVD and NASH
This study is looking at how targeting certain receptors in immune cells might help improve health for people with non-alcoholic fatty liver disease and heart problems by using special compounds to boost the function of these receptors.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10908531 on NIH RePORTER |
What this research studies
This research investigates how targeting liver X receptors (LXRs) in specific immune cells can help treat conditions like non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD). The study focuses on understanding the role of these receptors in liver and artery wall macrophages, which are crucial in the development of these diseases. By using desmosterol mimetics, the research aims to reverse the impaired function of these receptors, potentially leading to better health outcomes for patients with these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with non-alcoholic fatty liver disease or cardiovascular disease, particularly those with obesity or insulin resistance.
Not a fit: Patients without liver disease or cardiovascular issues may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve liver and heart health for millions of patients suffering from NAFLD and CVD.
How similar studies have performed: Previous research has shown promising results in targeting LXRs for similar health conditions, indicating that this approach has potential for success.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Glass, Christopher K — University of California, San Diego
- Study coordinator: Glass, Christopher K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.