Targeting specific kinases to treat a type of brain cancer
Co-targeting S6 and TAM kinases in PTEN-deficient glioblastoma
This study is looking at how blocking certain proteins can help make glioblastoma cells, especially in patients with a specific gene issue, more sensitive to treatments, with the hope of finding better ways to fight their cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10740887 on NIH RePORTER |
What this research studies
This research investigates the effects of inhibiting two specific kinases, S6 and TAM, in glioblastoma patients who have a deficiency in the PTEN tumor suppressor gene. By using advanced techniques like CRISPR Cas9 genome editing, the study aims to understand how these kinases interact and contribute to cancer cell survival. The goal is to identify new treatment strategies that could make PTEN-deficient glioblastoma cells more vulnerable to existing therapies. Patients may benefit from a more effective treatment approach that targets the unique vulnerabilities of their cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with PTEN-deficient glioblastoma.
Not a fit: Patients with glioblastoma that does not involve PTEN deficiency may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for patients with PTEN-deficient glioblastoma.
How similar studies have performed: Previous research has shown promising results in targeting similar kinases in cancer treatment, indicating potential for success in this approach.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Plas, David R — University of Cincinnati
- Study coordinator: Plas, David R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.