Targeting specific immune cells to treat chronic dental inflammation
Therapeutic Targeting of Apical Periodontal T-Cells in Chronic Oral Inflammation
This study is looking at a type of immune cell that causes inflammation in dental infections, like apical periodontitis, to find new treatments that can help reduce this inflammation and improve your oral health.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11033958 on NIH RePORTER |
What this research studies
This research focuses on understanding and targeting a specific type of immune cell, known as Th17 cells, that plays a significant role in chronic inflammation related to dental infections, particularly apical periodontitis. By investigating the mechanisms through which these cells contribute to the disease, the research aims to develop targeted therapies that could alleviate inflammation and improve oral health. The approach includes advanced techniques like single-cell RNA sequencing to analyze the behavior of these immune cells in the context of dental disease. Patients may benefit from new treatment options that specifically address the underlying immune responses involved in their condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic apical periodontitis or related inflammatory dental conditions.
Not a fit: Patients with acute dental infections or those without chronic inflammatory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for chronic oral inflammation, improving dental health and quality of life for affected patients.
How similar studies have performed: Previous research has shown promise in targeting immune cells for treating chronic inflammatory diseases, suggesting that this approach may be effective for apical periodontitis as well.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Hasiakos, Spyridon Peter — University of California Los Angeles
- Study coordinator: Hasiakos, Spyridon Peter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.