Targeting specific immune cells in the lungs to understand asthma better
Genetic targeting of intraepithelial mast cells
This study is looking at how certain immune cells called mast cells affect asthma and other breathing problems, using special mice to see how these cells behave during inflammation, which could help develop better treatments for patients like you.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11090540 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of mast cells, a type of immune cell, in respiratory diseases like asthma. By creating a special mouse model that allows researchers to track these cells in the lungs, the study aims to uncover how these mast cells contribute to airway inflammation and disease progression. The approach involves using advanced genetic techniques to selectively target and observe these cells during inflammation, which could lead to new insights into asthma treatment. Patients may benefit from improved therapies based on the findings of this research.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from asthma or other airway inflammatory diseases.
Not a fit: Patients with non-respiratory conditions or those not affected by asthma or airway inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for asthma and related respiratory conditions.
How similar studies have performed: Previous research has shown that targeting specific immune cells can lead to significant improvements in asthma treatment, indicating a promising approach.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Dwyer, Daniel F — Brigham and Women's Hospital
- Study coordinator: Dwyer, Daniel F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.