Targeting specific enzymes to prevent preterm labor
Official title: Selective targeting of matrix metalloproteinases for developing preterm labor therapeutics
Funded at University of Nevada Reno · NIH-10691338 · Data updated 2026-11-12
This study is looking at how certain enzymes are linked to preterm labor in women, and it aims to create new treatments that can help relax the uterus and prevent early contractions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nevada Reno NIH-funded |
| Lab location | 1 site (Reno, United States) |
| Project start | March 1, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $187,308 |
| NIH project number | 5R21HD109743-02 |
| Project ID | NIH-10691338 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant women who are at risk of preterm labor due to elevated levels of MMP-2 and MMP-9.
✕Less likely to help
Patients who are not pregnant or those who do not have elevated levels of MMP-2 and MMP-9 may not benefit from this research.
What this research studies
This research investigates the role of certain enzymes, known as matrix metalloproteinases (MMP-2 and MMP-9), which are found in higher levels in women experiencing preterm labor. The study aims to develop new therapeutic agents that can selectively inhibit these enzymes to help maintain uterine relaxation and prevent premature contractions. By using advanced protein engineering techniques, the researchers will create modified proteins that can effectively block these enzymes without affecting other important cellular functions. The ultimate goal is to provide a new treatment option for women at risk of preterm labor.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce the incidence of preterm labor, improving outcomes for both mothers and infants.
How similar studies have gone: Previous research has shown promise in targeting MMPs for various therapeutic applications, indicating potential success for this novel approach.
Where this research is happening
-
University of Nevada Reno
Reno, United States Active
Researchers
- Principal investigator: Raeeszadeh Sarmazdeh, Maryam — University of Nevada Reno
- Study coordinator: Raeeszadeh Sarmazdeh, Maryam
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.