Targeting specific enzymes to help treat Alzheimer's disease
Targeting carbonic anhydrases in Alzheimer's disease
This study is looking at how two approved medications might help protect brain cells and improve thinking skills in people with Alzheimer's by keeping the energy factories in their cells healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10602459 on NIH RePORTER |
What this research studies
This research investigates the role of carbonic anhydrases in Alzheimer's disease, focusing on how preserving mitochondrial function can prevent brain cell death and cognitive decline. The study explores the effects of two FDA-approved medications, methazolamide and acetazolamide, which inhibit these enzymes and may protect against the damaging processes associated with Alzheimer's. By examining both laboratory models and potential clinical applications, the research aims to understand how these treatments can improve brain health in patients with Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those experiencing cognitive decline associated with aging.
Not a fit: Patients with other forms of dementia or cognitive impairment unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic options that slow the progression of Alzheimer's disease and improve cognitive function.
How similar studies have performed: Previous research has shown promising results with similar approaches targeting mitochondrial function in Alzheimer's disease, suggesting potential for success in this study.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Fossati, Silvia — Temple Univ of the Commonwealth
- Study coordinator: Fossati, Silvia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.