Targeting specific channels to reduce severe pancreatitis caused by a common virus in children
Official title: Targeting transient receptor potential channels to suppress proviral mitochondrial fission and mitophagy in order to mitigate CVB pancreatitis
Funded at University of Texas Dallas · NIH-11291589 · Data updated 2026-11-12
This study is looking at how a virus called Coxsackievirus B can harm the pancreas in children and aims to find ways to protect pancreatic cells from damage and inflammation caused by the virus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Dallas NIH-funded |
| Lab location | 1 site (Richardson, United States) |
| Project start | December 7, 2021 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $343,200 |
| NIH project number | 7R01DK125692-05 |
| Project ID | NIH-11291589 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 11 years old who have been diagnosed with acute pancreatitis related to Coxsackievirus B infection.
✕Less likely to help
Patients who are older than 11 years or those with pancreatitis not related to Coxsackievirus B may not benefit from this research.
What this research studies
This research investigates how Coxsackievirus B (CVB), a virus that can lead to severe pancreatitis, affects mitochondrial function in pancreatic cells. The study aims to understand the mechanisms by which CVB causes inflammation and damage, particularly in children who are at higher risk. By focusing on transient receptor potential (TRP) channels, the researchers hope to find ways to block harmful processes that allow the virus to thrive and cause disease. The approach involves both laboratory experiments and potential therapeutic strategies to mitigate the effects of the virus on the pancreas.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the severity of pancreatitis in children infected with CVB.
How similar studies have gone: Previous research has shown promise in targeting mitochondrial dynamics to combat viral infections, suggesting that this approach may be effective.
Where this research is happening
-
University of Texas Dallas
Richardson, United States Active
Researchers
- Principal investigator: Sin, Jon — University of Texas Dallas
- Study coordinator: Sin, Jon
Related research
Other NIH-funded projects on the same topics.
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Chronic Pancreatitis and Related Conditions Data Center Supports Multi-Center Research
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-
Lymphatic roles in pancreatitis and recovery
This project looks at how the lymphatic system influences inflammation and healing in pancreatitis, using mouse models to identify new therapeutic targets.
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Diabetes after acute pancreatitis: understanding and tracking progression
A patient-focused look at how diabetes can develop after an episode of acute pancreatitis, using data from a large, ongoing study and AI insights.
-
Continuation of Type 1 Diabetes in Acute Pancreatitis: UF Health and AdventHealth
A patient-facing overview of a long-term study tracking people with acute pancreatitis to understand how some develop type 1 diabetes later and what factors influence that process.
-
Data Coordinating Center for Type 1 Diabetes in Acute Pancreatitis Consortium
A national effort to learn how pancreatitis-related Type 1 diabetes develops, by tracking patients and coordinating data to improve future care.
-
Diabetes after acute pancreatitis: a patient-focused network study
A program at Indiana University is studying how diabetes can develop after an acute pancreatitis episode, with new findings that could help doctors tailor care for adults who had pancreatitis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.