Targeting specific channels to reduce severe pancreatitis caused by a common virus in children
Targeting transient receptor potential channels to suppress proviral mitochondrial fission and mitophagy in order to mitigate CVB pancreatitis
This study is looking at how a virus called Coxsackievirus B can harm the pancreas in children and aims to find ways to protect pancreatic cells from damage and inflammation caused by the virus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Dallas NIH-funded |
| Lab location | 1 site (Richardson, United States) |
| Project ID | NIH-11291589 on NIH RePORTER |
What this research studies
This research investigates how Coxsackievirus B (CVB), a virus that can lead to severe pancreatitis, affects mitochondrial function in pancreatic cells. The study aims to understand the mechanisms by which CVB causes inflammation and damage, particularly in children who are at higher risk. By focusing on transient receptor potential (TRP) channels, the researchers hope to find ways to block harmful processes that allow the virus to thrive and cause disease. The approach involves both laboratory experiments and potential therapeutic strategies to mitigate the effects of the virus on the pancreas.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who have been diagnosed with acute pancreatitis related to Coxsackievirus B infection.
Not a fit: Patients who are older than 11 years or those with pancreatitis not related to Coxsackievirus B may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the severity of pancreatitis in children infected with CVB.
How similar studies have performed: Previous research has shown promise in targeting mitochondrial dynamics to combat viral infections, suggesting that this approach may be effective.
Where this research is happening
Richardson, United States
- University of Texas Dallas — Richardson, United States (Active)
Researchers
- Principal investigator: Sin, Jon — University of Texas Dallas
- Study coordinator: Sin, Jon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.