Targeting specific cells to reduce pain and degeneration in jaw joints
Official title: Targeting P21 positive senescent cells for alleviating TMJ degeneration
Funded at University of Nebraska Medical Center · NIH-10890439 · Data updated 2026-11-12
This study is looking at how certain aging cells might be causing pain and problems in the jaw joint, especially for older adults or those who are overweight, and it aims to find new ways to get rid of these cells to help improve their quality of life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | September 5, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $399,198 |
| NIH project number | 1R01DE033004-01A1 |
| Project ID | NIH-10890439 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from TMJ degeneration, particularly those who are obese or elderly.
✕Less likely to help
Patients with TMJ degeneration who do not have obesity or age-related factors may not benefit from this research.
What this research studies
This research investigates the role of p21 positive senescent cells in the degeneration of the temporomandibular joint (TMJ), a condition that affects millions and causes significant pain. The study aims to develop innovative methods to target and eliminate these cells, which are believed to contribute to the deterioration of joint health, particularly in individuals who are obese or elderly. By using advanced genetic and therapeutic techniques, the research seeks to improve the quality of life for those suffering from TMJ degeneration. Patients may be involved in clinical evaluations to assess the effectiveness of these new treatment approaches.
Why it matters
Potential benefit: If successful, this research could lead to effective treatments that alleviate pain and improve joint function for patients with TMJ degeneration.
How similar studies have gone: While targeting senescent cells is a novel approach, similar strategies have shown promise in other degenerative conditions, suggesting potential for success in this area.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Yadav, Sumit — University of Nebraska Medical Center
- Study coordinator: Yadav, Sumit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.