Targeting specific cell types in heart disease related to arrhythmias
Cell type-Specific Therapeutic Targeting of canonical WNT Pathway in Arrhythmogenic Cardiomyopathy
This study is looking at a heart condition called arrhythmogenic cardiomyopathy (ACM) to understand how certain proteins in heart cells work together and how this knowledge could help create better treatments for people with ACM.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10594529 on NIH RePORTER |
What this research studies
This research investigates arrhythmogenic cardiomyopathy (ACM), a genetic heart disease that leads to dangerous heart rhythms and sudden death. The study focuses on the role of desmosome proteins in heart cells and how they interact with the canonical WNT pathway, which is crucial for heart function. By understanding the specific contributions of different cell types in the heart, the research aims to develop targeted therapies that could improve outcomes for patients with ACM.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with arrhythmogenic cardiomyopathy, particularly those with genetic mutations affecting desmosome proteins.
Not a fit: Patients without arrhythmogenic cardiomyopathy or those with other unrelated heart conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with arrhythmogenic cardiomyopathy, potentially reducing the risk of sudden cardiac events.
How similar studies have performed: While the approach of targeting the canonical WNT pathway in heart disease is being explored, the specific focus on cell type-specific targeting in ACM is relatively novel and has not been extensively tested.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Marian, Ali J — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Marian, Ali J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.