Targeting solid tumors with advanced CAR T cells and imaging
Dual-targeted DOTA CAR T cells with image-guided monitoring for solid tumor treatment
This study is testing a new kind of CAR T cell therapy that can be safely controlled and tracked after it's given to cancer patients, using special technology to help doctors see how well the treatment is working against tumors.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10879575 on NIH RePORTER |
What this research studies
This research focuses on developing a new type of CAR T cell therapy that can be controlled and monitored after being infused into patients. The approach involves genetically engineering T cells to recognize specific tumor markers, allowing for personalized treatment. Additionally, the therapy incorporates imaging technology to track the location and activity of the CAR T cells in real-time, which aims to enhance safety and effectiveness in treating solid tumors. By using a combination of targeted biologics and advanced imaging, the researchers hope to improve outcomes for cancer patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with solid tumors that express specific folate receptors.
Not a fit: Patients with tumors that do not express the targeted folate receptors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatments for patients with solid tumors.
How similar studies have performed: Previous research has shown promise in using CAR T cell therapies for various cancers, but this specific approach with imaging and dual-targeting is novel.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Powell, Daniel J. — University of Pennsylvania
- Study coordinator: Powell, Daniel J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.