Targeting SIRT1 to improve treatments for endometriosis
SIRT1 as a Therapeutic Target in Endometriosis
This study is looking at how a protein called SIRT1 might be involved in why some women with endometriosis don't respond well to progesterone treatment, and it's hoping to find new ways to diagnose and treat this condition to help those affected feel better.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10925403 on NIH RePORTER |
What this research studies
This research investigates the role of SIRT1, a histone deacetylase, in the progesterone resistance associated with endometriosis. By utilizing mouse and non-human primate models, as well as human tissues, the study aims to understand how SIRT1 contributes to the chronic inflammation and self-sustaining nature of endometriosis. The researchers will explore innovative diagnostic and therapeutic approaches to address this condition, potentially leading to improved treatment options for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with endometriosis, particularly those experiencing progesterone resistance and related infertility issues.
Not a fit: Patients without endometriosis or those who do not experience progesterone resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new diagnostic tools and therapies that effectively manage endometriosis and its associated infertility.
How similar studies have performed: Previous research has shown promise in targeting similar pathways in other conditions, suggesting potential for success in this novel approach to endometriosis.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Jeong, Jae-Wook — Duke University
- Study coordinator: Jeong, Jae-Wook
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.