Targeting RNA splicing to improve treatment for triple-negative breast cancer
Therapeutic Targeting of RNA Splicing in Triple-Negative Breast Cancer
This study is looking at ways to boost the immune system's ability to fight triple-negative breast cancer by changing how certain RNA is spliced, which could lead to better treatments for patients facing this tough type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11116984 on NIH RePORTER |
What this research studies
This research focuses on triple-negative breast cancer (TNBC), a challenging subtype of breast cancer that often does not respond well to existing therapies. The team aims to explore how manipulating RNA splicing can enhance the immune response against TNBC, potentially making immunotherapies more effective. By investigating the types of mis-spliced RNA that can stimulate an immune reaction, the researchers hope to develop new treatment strategies that could improve patient outcomes. This approach combines insights from cancer biology and immunology to address the unique challenges posed by TNBC.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with triple-negative breast cancer who may not have responded well to current treatment options.
Not a fit: Patients with other subtypes of breast cancer or those who do not have a diagnosis of breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with triple-negative breast cancer, improving their chances of response to immunotherapy.
How similar studies have performed: Previous studies have shown promise in using spliceosome-targeted therapies to engage the immune system in cancer treatment, indicating a potential for success in this novel approach.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Westbrook, Thomas — Baylor College of Medicine
- Study coordinator: Westbrook, Thomas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.