Targeting RNA-protein interactions to develop new treatments for diseases.
Official title: Chemical approaches for targeting ribonucleoprotein assemblies
Funded at St. Jude Children's Research Hospital · NIH-10941909 · Data updated 2026-11-12
This study is looking at how certain interactions between RNA and proteins affect gene activity and can lead to diseases like cancer and brain disorders, with the goal of finding new drugs that can help improve treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | September 10, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $462,500 |
| NIH project number | 1R35GM155423-01 |
| Project ID | NIH-10941909 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with cancers or neurodegenerative diseases that may be influenced by RNA-protein assembly disruptions.
✕Less likely to help
Patients with conditions unrelated to RNA-protein interactions or those not affected by the diseases being targeted may not benefit from this research.
What this research studies
This research investigates how RNA-protein interactions influence gene expression and contribute to various diseases, including cancer and neurodegenerative disorders. The team aims to discover chemical compounds that can selectively modulate RNA-protein assemblies by targeting specific proteins known as DEAD-box ATPases. By understanding and manipulating these interactions, the research seeks to develop new therapeutic strategies that could lead to innovative treatments. Patients may benefit from advancements in drug development that arise from this work.
Why it matters
Potential benefit: If successful, this research could lead to new drugs that effectively treat diseases linked to RNA-protein interactions.
How similar studies have gone: Previous research has shown promise in targeting RNA-protein interactions for therapeutic purposes, indicating that this approach could be viable.
Where this research is happening
-
St. Jude Children's Research Hospital
Memphis, United States Active
Researchers
- Principal investigator: Cupido, Tommaso — St. Jude Children's Research Hospital
- Study coordinator: Cupido, Tommaso
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.