Targeting RNA delivery to specific areas in the body using nanocarriers
Vascular Targeting of Nanocarriers for RNA
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-10767818
This study is exploring new ways to deliver RNA treatments directly to inflamed areas in the body, like the lungs and brain, to help improve therapies for patients dealing with inflammation.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10767818 on ClinicalTrials.gov |
What this research studies
This research focuses on developing advanced nanocarriers that can deliver RNA to specific sites in the body, particularly targeting inflamed areas such as the lungs and brain. By utilizing modifications in RNA and a strategy called vascular targeting, the researchers aim to enhance the effectiveness of RNA therapies. The approach involves using specialized ligands that guide these nanocarriers to accumulate in desired tissues, potentially improving treatment outcomes for conditions involving inflammation. Patients may benefit from more effective therapies that directly address their specific health issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from inflammatory diseases affecting the lungs or brain.
Not a fit: Patients with non-inflammatory conditions or those not requiring RNA-based therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective RNA-based therapies for patients with inflammatory conditions.
How similar studies have performed: Previous research has shown promise in using nanocarriers for targeted drug delivery, indicating potential success for this novel approach.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MUZYKANTOV, VLADIMIR R — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: MUZYKANTOV, VLADIMIR R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.