Targeting RNA decay in blood cancers with splicing mutations.
Official title: Targeting Nonsense-Mediated RNA Decay in Splicing Factor Mutant Myeloid Malignancies.
Funded at Washington University · NIH-10975353 · Data updated 2026-11-12
This study is looking at how specific changes in genes related to RNA processing can make blood cancers like acute myeloid leukemia and myelodysplastic syndromes more treatable by using therapies that target these changes, with the hope of helping patients get better outcomes.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $34,926 |
| NIH project number | 5F31CA284751-02 |
| Project ID | NIH-10975353 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) who have mutations in splicing factor genes.
✕Less likely to help
Patients without splicing factor mutations or those with other types of blood cancers may not benefit from this research.
What this research studies
This research investigates how certain mutations in splicing factor genes contribute to blood cancers like acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). The approach focuses on the vulnerability of cancer cells with these mutations to treatments that disrupt RNA splicing. By understanding how these mutations lead to the production of faulty RNA, the research aims to develop targeted therapies that exploit this weakness, potentially improving treatment outcomes for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new, more effective treatments for patients with specific blood cancers caused by splicing factor mutations.
How similar studies have gone: Other research has shown promising results in targeting splicing mutations in cancer, indicating that this approach may be effective.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Cabrera, Claudia — Washington University
- Study coordinator: Cabrera, Claudia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.