Targeting rising HIV risk groups in rural South Africa during COVID-19

The changing face of HIV in the era of COVID-19: Maximising HIV incidence reduction through dynamic targeting of current and future distributions of acquisition risk.

NIH-funded research Stellenbosch University · NIH-11489951

This project will find which people and places in rural KwaZulu-Natal are now most at risk of getting HIV so prevention can be aimed where it will help the most.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionStellenbosch University NIH-funded
Lab location1 site (Stellenbosch, SOUTH AFRICA)
Project IDNIH-11489951 on NIH RePORTER

What this research studies

If I live in rural KwaZulu-Natal, the team will use long-running community health data from the Africa Health Research Institute to spot changes in who is getting infected with HIV over time and space. They will look at effects of COVID-19 disruptions and the shift to new antiretroviral drugs to identify new vulnerable age, sex, and location groups. Using these findings, the researchers plan to design combination prevention approaches that focus on those emerging high-risk groups. The goal is to enable programs to reach people who are now being missed by current efforts.

Who could benefit from this research

Good fit: People living in rural KwaZulu-Natal and similar high HIV-burden communities in South Africa—especially those in newly identified age, sex, or location risk groups—would be the primary candidates for participation or program benefits.

Not a fit: People who live outside the study area or who are already fully engaged in effective prevention and treatment programs are less likely to see direct benefit from this grant's activities.

Why it matters

Potential benefit: If successful, the work could help direct prevention and treatment to the people and areas most likely to get HIV, lowering new infections and improving care where it is needed.

How similar studies have performed: Past efforts to expand treatment and prevention have cut infections, and targeted approaches have shown promise, but using dynamic, geography- and age-specific targeting in the COVID-19 era is a newer approach.

Where this research is happening

Stellenbosch, SOUTH AFRICA

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Acquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome Virus
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.