Targeting reactive astrocytes in Alzheimer's disease and related dementias
Strategies for targeting astrocyte reactivity in Alzheimer's disease and related dementias
This study is looking at how certain brain cells called reactive astrocytes might affect Alzheimer's disease and other types of dementia, using special techniques in mice and human studies to see how changing these cells could help understand and possibly slow down the disease.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-10897071 on NIH RePORTER |
What this research studies
This research investigates the role of reactive astrocytes in Alzheimer's disease and related dementias by using advanced techniques to understand their functions. The team will employ cell-specific targeting to modify the behavior of these astrocytes and assess their impact in preclinical mouse models. Additionally, they will validate their findings using resources from the University of Kentucky's Alzheimer's Disease Research Center, including studies on living human subjects. The goal is to uncover how these astrocyte phenotypes contribute to the progression of dementia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with other forms of dementia not related to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve outcomes for patients with Alzheimer's disease and related dementias.
How similar studies have performed: While the investigation of astrocyte roles in dementia is gaining attention, this specific approach is relatively novel and has not been extensively tested in large-scale studies.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Norris, Christopher Mark — University of Kentucky
- Study coordinator: Norris, Christopher Mark
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.