Targeting proteins that help colorectal cancer cells survive
Assessment of strategies for targeting transcriptional co-activators in colorectal cancer
['FUNDING_R37'] · UNIVERSITY OF NEBRASKA MEDICAL CENTER · NIH-10943743
This study is looking at how specific proteins help colorectal cancer cells, especially those with K-Ras mutations, survive and grow, with the goal of finding new ways to stop these cancer cells and improve treatment options for patients.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEBRASKA MEDICAL CENTER (nih funded) |
| Locations | 1 site (OMAHA, UNITED STATES) |
| Trial ID | NIH-10943743 on ClinicalTrials.gov |
What this research studies
This research investigates how certain proteins, known as transcriptional coactivators, contribute to the survival of colorectal cancer cells, particularly those with K-Ras mutations. The team will use advanced techniques, including mass spectrometry, to identify the interactions between these proteins and other cellular components that promote cancer growth. By understanding these mechanisms, the researchers aim to develop strategies to inhibit the signaling pathways that allow cancer cells to thrive, potentially leading to new treatment options for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with colorectal cancer, especially those with K-Ras mutations.
Not a fit: Patients with colorectal cancer who do not have K-Ras mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that specifically target and inhibit the growth of colorectal cancer cells.
How similar studies have performed: Other research has shown promising results in targeting transcriptional coactivators in various cancers, suggesting that this approach could be effective.
Where this research is happening
OMAHA, UNITED STATES
- UNIVERSITY OF NEBRASKA MEDICAL CENTER — OMAHA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FISHER, KURT — UNIVERSITY OF NEBRASKA MEDICAL CENTER
- Study coordinator: FISHER, KURT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.