Targeting proteins that help colorectal cancer cells survive
Official title: Assessment of strategies for targeting transcriptional co-activators in colorectal cancer
Funded at University of Nebraska Medical Center · NIH-10943743 · Data updated 2026-11-12
This study is looking at how specific proteins help colorectal cancer cells, especially those with K-Ras mutations, survive and grow, with the goal of finding new ways to stop these cancer cells and improve treatment options for patients.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $439,367 |
| NIH project number | 1R37CA293214-01 |
| Project ID | NIH-10943743 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with colorectal cancer, especially those with K-Ras mutations.
✕Less likely to help
Patients with colorectal cancer who do not have K-Ras mutations may not benefit from this research.
What this research studies
This research investigates how certain proteins, known as transcriptional coactivators, contribute to the survival of colorectal cancer cells, particularly those with K-Ras mutations. The team will use advanced techniques, including mass spectrometry, to identify the interactions between these proteins and other cellular components that promote cancer growth. By understanding these mechanisms, the researchers aim to develop strategies to inhibit the signaling pathways that allow cancer cells to thrive, potentially leading to new treatment options for patients.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that specifically target and inhibit the growth of colorectal cancer cells.
How similar studies have gone: Other research has shown promising results in targeting transcriptional coactivators in various cancers, suggesting that this approach could be effective.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Fisher, Kurt — University of Nebraska Medical Center
- Study coordinator: Fisher, Kurt
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.