Targeting proteins involved in stress granule formation in Alzheimer's disease
Official title: Nanobodies targeting stress granule components
Funded at University of Connecticut Storrs · NIH-10739370 · Data updated 2026-11-12
This study is looking at how tiny structures in our cells, called stress granules, might play a part in the development of Alzheimer's disease, and it's for anyone interested in understanding more about what causes this condition and how we might find new ways to treat it.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Storrs NIH-funded |
| Lab location | 1 site (Storrs-Mansfield, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $460,800 |
| NIH project number | 1R21AG083761-01 |
| Project ID | NIH-10739370 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
✕Less likely to help
Patients with other forms of dementia not related to Alzheimer's or those without cognitive impairments may not benefit from this research.
What this research studies
This research investigates the role of stress granules, which are cellular structures formed by RNA-binding proteins, in the development of Alzheimer's disease. By studying how these proteins behave under stress and their interactions with tau proteins, the research aims to uncover new mechanisms that contribute to the disease. The approach includes advanced techniques to observe these proteins in living cells without disrupting their natural concentrations. This could lead to a better understanding of Alzheimer's pathology and potential new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that slow down or prevent the progression of Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of RNA-binding proteins in neurodegenerative diseases, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Connecticut Storrs
Storrs-Mansfield, United States Active
Researchers
- Principal investigator: Cho, Yongku Peter — University of Connecticut Storrs
- Study coordinator: Cho, Yongku Peter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.