Targeting PDE2a to treat long-term effects of mild traumatic brain injury in soldiers
Official title: PDE2a inhibition as a therapeutic target for the chronic effects of repetitive mild TBI
Funded at James a. Haley VA Medical Center · NIH-11000525 · Data updated 2026-11-12
This study is looking at how blocking a specific enzyme might help soldiers who have had repeated mild brain injuries feel better and think more clearly, using mouse models to find the best ways to help them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | James a. Haley VA Medical Center NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | October 1, 2024 |
| Project end | September 30, 2028 |
| Funding year | 2025 |
| NIH project number | 1I01RX004814-01A2 |
| Project ID | NIH-11000525 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include military personnel and veterans who have experienced repetitive mild traumatic brain injuries.
✕Less likely to help
Patients who have not experienced any form of traumatic brain injury may not benefit from this research.
What this research studies
This research investigates the potential of inhibiting PDE2a as a therapeutic approach to address the chronic effects of repetitive mild traumatic brain injury (r-mTBI) experienced by soldiers. The study utilizes various mouse models to simulate the neurobehavioral and biochemical consequences of r-mTBI, aiming to identify effective treatment strategies. By understanding the molecular responses to TBI, the research seeks to develop better interventions that could improve cognitive and emotional outcomes for affected individuals. The focus is on addressing the significant burden of TBI on military personnel and their families.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve the quality of life for soldiers suffering from the long-term effects of mild traumatic brain injury.
How similar studies have gone: Previous research has shown promise in targeting molecular pathways related to TBI, indicating that this approach may lead to meaningful advancements in treatment.
Where this research is happening
-
James a. Haley VA Medical Center
Tampa, United States Active
Researchers
- Principal investigator: Crawford, Fiona C. — James a. Haley VA Medical Center
- Study coordinator: Crawford, Fiona C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.