Targeting pancreatic cancer with specialized radiation therapy
Official title: Lysosome Trapped FAP-Targeted Theranostics for Pancreatic Cancer
Funded at University of Nebraska Medical Center · NIH-11057686 · Data updated 2026-11-12
This study is looking at a new way to treat pancreatic cancer by using special treatments that deliver radiation directly to the tumor, helping to make the therapy more effective while protecting healthy tissue around it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | March 18, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $626,716 |
| NIH project number | 5R01CA290859-02 |
| Project ID | NIH-11057686 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with pancreatic ductal adenocarcinoma, especially those with advanced or metastatic disease.
✕Less likely to help
Patients with early-stage pancreatic cancer or those who do not express fibroblast activation protein may not benefit from this research.
What this research studies
This research focuses on improving treatment for pancreatic ductal adenocarcinoma (PDAC) by using targeted radionuclide therapeutics (TRTs) that specifically target tumor-associated fibroblasts. The approach involves developing low-molecular-weight carriers that can deliver radiation directly to the tumor while minimizing damage to surrounding healthy tissue. By enhancing the retention of these therapeutic agents within the tumor, the study aims to increase the effectiveness of radiation therapy for patients with PDAC, particularly those with metastatic disease.
Why it matters
Potential benefit: If successful, this research could lead to more effective and less toxic treatment options for patients with pancreatic cancer.
How similar studies have gone: Previous studies have shown promise with targeted radionuclide therapies in other cancers, indicating potential for success in this novel approach for pancreatic cancer.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Garrison, Jered C — University of Nebraska Medical Center
- Study coordinator: Garrison, Jered C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.