Targeting oxidative pathways in Alzheimer's disease
Official title: Novel oxidative pathway targets microglia in Alzheimer's disease
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11160533 · Data updated 2026-11-12
This study is looking at how oxidative stress impacts brain cells important for health in people with Alzheimer's, and it aims to find new ways to help these cells work better and improve brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | August 15, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $767,342 |
| NIH project number | 5R01AG082382-02 |
| Project ID | NIH-11160533 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease, particularly those experiencing cognitive decline.
✕Less likely to help
Patients with early-stage Alzheimer's or those without significant cognitive impairment may not benefit from this research.
What this research studies
This research investigates how oxidative stress affects microglial cells in Alzheimer's disease, which are crucial for brain health. By analyzing human cases and utilizing molecular and cellular techniques, the study aims to uncover the mechanisms behind microglial dysfunction and its impact on Alzheimer's pathology. The researchers will explore new therapeutic strategies that involve compounds designed to neutralize oxidative stress, potentially improving the function of microglia and overall brain health in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function and quality of life for patients with Alzheimer's disease.
How similar studies have gone: Other research has shown promise in targeting oxidative stress pathways in neurodegenerative diseases, suggesting potential for success in this novel approach.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Byzova, Tatiana V — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Byzova, Tatiana V
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.