Targeting nutrient dependency in pancreatic cancer
Disrupting glutathione dependency in pancreatic cancer
This study is looking at how pancreatic cancer cells rely on certain nutrients, like cysteine, to survive when there aren't many resources available, with the goal of finding new ways to make treatments more effective for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-11004335 on NIH RePORTER |
What this research studies
This research investigates how pancreatic ductal carcinoma (PDAC) cells depend on specific nutrients, particularly cysteine, to survive and grow in a nutrient-limited environment. By analyzing the metabolic processes of PDAC cells, the study aims to uncover new therapeutic strategies that could disrupt this dependency and enhance treatment effectiveness. The research employs metabolomics profiling and gene expression analysis to understand the mechanisms that allow PDAC cells to thrive despite limited nutrient availability. This could lead to innovative approaches to improve patient outcomes in pancreatic cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pancreatic ductal carcinoma who are seeking new treatment options.
Not a fit: Patients with other types of cancer or those who do not have pancreatic ductal carcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve survival rates for patients with pancreatic cancer.
How similar studies have performed: Previous research has shown promising results in targeting metabolic dependencies in cancer, suggesting that this approach could be effective.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Nwosu, Zeribe Chike — Cornell University
- Study coordinator: Nwosu, Zeribe Chike
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.