Targeting Mitochondria to Improve Outcomes After Brain Injury in Children
Druggable Mitochondrial Targets for Treatment of Cerebral Ischemia
This study is looking at a new treatment to help critically ill babies and children with brain injuries from things like cardiac arrest or stroke, aiming to improve their chances of recovery and overall quality of life by protecting their brain cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10775809 on NIH RePORTER |
What this research studies
This research focuses on improving the survival and quality of life for critically ill infants and children suffering from brain injuries caused by conditions like cardiac arrest or stroke. The approach involves developing new therapeutics that target mitochondria to preserve cellular energy and prevent cell death. By inhibiting a specific enzyme linked to energy depletion in brain cells, the study aims to enhance recovery from hypoxic-ischemic encephalopathy (HIE). Patients may be monitored for improvements in neurological outcomes as a result of this innovative treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include critically ill infants and children who have experienced brain injuries due to cardiac arrest, stroke, or other severe conditions.
Not a fit: Patients with brain injuries not related to hypoxic-ischemic encephalopathy or those who are not critically ill may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery and quality of life for children affected by severe brain injuries.
How similar studies have performed: Previous research has shown promise in targeting mitochondrial functions to improve outcomes in brain injury, suggesting that this approach may be effective.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Clark, Robert S B — University of Pittsburgh at Pittsburgh
- Study coordinator: Clark, Robert S B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.