Targeting microglial cells to improve Alzheimer's disease treatment
Alzheimer's Disease Therapy via the MR Image-Guided Deletion of Microglial SHIP-1 with Focused Ultrasound
This study is exploring a new way to help people with Alzheimer's by using focused ultrasound to deliver treatments that help brain cells clear harmful plaques, with the hope of improving memory and thinking skills without causing extra inflammation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11130730 on NIH RePORTER |
What this research studies
This research investigates a novel approach to treat Alzheimer's disease by targeting microglial cells, which are crucial in the disease's progression. The study aims to use MR image-guided focused ultrasound to deliver therapies that inhibit the SHIP-1 protein in microglia, enhancing their ability to clear amyloid beta plaques from the brain. By selectively targeting these cells, the research seeks to improve neuronal health and cognitive function without causing widespread inflammation. Patients may benefit from this innovative method that aims to restore brain function in Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease, particularly those with late-onset forms of the condition.
Not a fit: Patients with early-onset Alzheimer's or those without significant amyloid beta plaque accumulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cognitive function and quality of life for patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in targeting microglial cells for Alzheimer's treatment, indicating potential for success in this approach.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Price, Richard J. — University of Virginia
- Study coordinator: Price, Richard J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.