Targeting metabolic vulnerabilities in brain tumors with specific mutations
Investigation of Sirt1 activation to target IDH mutant glioma
['FUNDING_CAREER'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10909219
This study is looking at a tough type of brain tumor called IDH mutant glioma that mainly affects younger adults, and it’s testing whether a special compound can help slow down tumor growth by boosting a metabolic regulator, with hopes of finding better treatments for patients like you.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10909219 on ClinicalTrials.gov |
What this research studies
This research investigates a type of brain tumor known as IDH mutant glioma, which is particularly aggressive and affects young to middle-aged adults. The study aims to explore how activating a metabolic regulator called Sirt1 can help stop the growth of these tumors. Researchers will use mouse models to test the effectiveness of Sirt1 activating compounds and their combination with cell cycle inhibitors to enhance treatment outcomes. By understanding the metabolic changes in these tumors, the goal is to develop more effective therapies for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are young to middle-aged adults diagnosed with IDH mutant gliomas.
Not a fit: Patients with other types of brain tumors or those who do not have IDH mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that significantly improve survival and quality of life for patients with IDH mutant gliomas.
How similar studies have performed: Previous research has shown promising results in targeting metabolic pathways in cancer, suggesting that this approach may be effective for IDH mutant gliomas as well.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MILLER, JULIE JOANN — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: MILLER, JULIE JOANN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.