Targeting mechanical stress and immune suppression in aggressive breast cancer
ATR: targeting mechanical stress induced EMT and immune suppression in triple negative breast cancer
This study is looking at how the pressure around triple negative breast cancer tumors can help the cancer grow and avoid the immune system, and it aims to find new ways to treat this type of cancer that might work better for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10892917 on NIH RePORTER |
What this research studies
This research investigates how mechanical stress in the tumor environment contributes to the progression of triple negative breast cancer (TNBC) by promoting a process called epithelial to mesenchymal transition (EMT). The study aims to understand the role of the ATR protein in this process and how it affects the cancer's ability to evade the immune system. By exploring the interactions between cancer cells and their surrounding environment, the research seeks to identify new therapeutic strategies to overcome resistance to existing treatments. Patients may be involved in trials that test these new approaches to improve outcomes for TNBC.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with triple negative breast cancer, particularly those who have not responded to standard therapies.
Not a fit: Patients with non-triple negative breast cancer or those who have already achieved remission may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve survival rates for patients with triple negative breast cancer.
How similar studies have performed: Previous research has shown promising results in targeting similar mechanisms in cancer, suggesting that this approach may be effective.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Mutter, Robert W — Mayo Clinic Rochester
- Study coordinator: Mutter, Robert W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.