Targeting LY6K with NSC243928 to boost immune response in TNBC

Who could benefit from this research

What this research studies

This project centers on TNBC, a aggressive breast cancer lacking targeted treatments. Researchers are exploring how NSC243928 binds LY6K, a protein found on many TNBC tumors, to enhance anti-tumor immunity and may affect how the tumor interacts with immune cells. The work builds on prior findings and uses molecular and immune-system analyses to understand how LY6K targeting changes tumor biology and chromatin. Outcomes could point to a new therapeutic approach that works with the immune system to control tumor growth in patients with TNBC.

Why it matters

Where this research is happening

• Henry M. Jackson Fdn for the Adv Mil/med
  Bethesda, United States Active

Researchers

• Principal investigator: Upadhyay, Geeta — Henry M. Jackson Fdn for the Adv Mil/med
• Study coordinator: Upadhyay, Geeta

Related research

Other NIH-funded projects on the same topics.

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• Rac-enhanced CAR-Macrophages against TNBC

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.