Targeting lung blood vessel cells to prevent lung damage
Theraputic targeting of pulmonary endothelial cells to inhibit pathological lung remodeling
This study is looking at how to make lung health better by focusing on the cells that line the blood vessels in the lungs, especially for people with pulmonary fibrosis, a condition that makes it hard to breathe; the researchers want to find new treatments that help these cells work better and stop lung damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-11057043 on NIH RePORTER |
What this research studies
This research investigates how to improve lung health by focusing on the cells that line blood vessels in the lungs, known as endothelial cells. It aims to understand their role in lung diseases like pulmonary fibrosis, which involves abnormal lung repair and can lead to severe breathing problems. The researchers will explore new treatments that involve delivering specific proteins or cells directly to these endothelial cells to enhance their function and prevent further lung damage. By using advanced techniques, they hope to find effective ways to stop the progression of lung fibrosis and improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary fibrosis or related lung diseases, particularly those experiencing significant lung damage.
Not a fit: Patients with early-stage lung conditions or those without significant pulmonary fibrosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve lung function and quality of life for patients with pulmonary fibrosis.
How similar studies have performed: While the approach of targeting endothelial cells in lung diseases is relatively novel, preliminary studies have shown promise in related areas, suggesting potential for success.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Kalin, Tanya — University of Arizona
- Study coordinator: Kalin, Tanya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.