Targeting kidney immune cells to slow down cystic kidney disease
Official title: Targeting kidney resident macrophage niche filling to slow cystic kidney disease
Funded at University of Oklahoma Hlth Sciences Ctr · NIH-11085060 · Data updated 2026-11-12
This study is looking at how certain immune cells in the kidneys might affect the growth of cysts in people with autosomal dominant polycystic kidney disease (ADPKD), and it aims to find a way to safely remove these cells to help slow down the disease and keep kidneys working better for longer.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $38,003 |
| NIH project number | 5F31DK137568-02 |
| Project ID | NIH-11085060 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autosomal dominant polycystic kidney disease (ADPKD).
✕Less likely to help
Patients with other forms of kidney disease or those who do not have ADPKD may not benefit from this research.
What this research studies
This research investigates how specific immune cells in the kidneys, known as kidney resident macrophages, contribute to the progression of autosomal dominant polycystic kidney disease (ADPKD). The study aims to develop a method to selectively deplete these macrophages in the kidneys without affecting other tissues, which is crucial for long-term treatment. By understanding the mechanisms behind these immune cells, the research seeks to provide a targeted approach to slow down the growth of cysts and preserve kidney function over time.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly slow the progression of cystic kidney disease, improving patients' quality of life.
How similar studies have gone: Previous research has shown that targeting immune cells can be effective in other diseases, suggesting potential success for this novel approach in ADPKD.
Where this research is happening
-
University of Oklahoma Hlth Sciences Ctr
Oklahoma City, United States Active
Researchers
- Principal investigator: Yashchenko, Alex — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Yashchenko, Alex
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.