Targeting interactions in the immune environment of pancreatic cancer
Targeting immune stroma interactions in pancreatic cancer
['FUNDING_R01'] · EMORY UNIVERSITY · NIH-10661565
This study is looking at how the surrounding tissue in pancreatic cancer affects the immune system and aims to improve treatments by helping immune cells better reach and fight the tumor, with the hope of making immunotherapy more effective for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-10661565 on ClinicalTrials.gov |
What this research studies
This research investigates how the fibrotic stroma in pancreatic ductal adenocarcinoma (PDAC) affects immune responses. It focuses on the interactions between tumor cells and immune suppressive cells, particularly the role of pancreatic stellate cells. By targeting a specific protein, Hsp90, the research aims to enhance the effectiveness of immunotherapy by improving immune cell access to the tumor microenvironment. The study includes clinical trials that will collect biopsies and blood samples to validate findings from laboratory models.
Who could benefit from this research
Good fit: Ideal candidates are patients diagnosed with pancreatic ductal adenocarcinoma who are eligible for immunotherapy treatments.
Not a fit: Patients with other types of cancer or those who are not eligible for immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved immunotherapy outcomes for patients with pancreatic cancer.
How similar studies have performed: Previous research has shown promising results with similar approaches targeting the tumor microenvironment in cancer treatment.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LESINSKI, GREGORY B. — EMORY UNIVERSITY
- Study coordinator: LESINSKI, GREGORY B.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers