Targeting interactions between lung cancer cells and brain cells to prevent brain metastasis
Targeting tumor-neural cell interactions to inhibit lung cancer brain metastasis
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-11037894
This study is looking at how lung cancer cells connect with brain cells to help the cancer spread to the brain, and it's hoping to find new treatments that can stop this from happening, which could help patients with lung cancer who are at risk of brain metastases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11037894 on ClinicalTrials.gov |
What this research studies
This research investigates how lung cancer cells interact with brain cells to promote the spread of cancer to the brain. By understanding the molecular mechanisms involved in this process, the researchers aim to develop new therapies that can effectively inhibit brain metastasis. The study focuses on the role of specific proteins that facilitate these interactions and explores the potential of drugs that can cross the blood-brain barrier to disrupt this process. Patients with lung cancer may benefit from insights gained in this research, leading to improved treatment options for brain metastases.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with lung cancer, particularly those who have or are at high risk for brain metastases.
Not a fit: Patients with lung cancer who do not have brain metastases or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve survival and quality of life for lung cancer patients with brain metastases.
How similar studies have performed: Previous research has shown promise in targeting similar molecular pathways to inhibit cancer metastasis, suggesting that this approach may yield beneficial results.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PENDERGAST, ANN MARIE — DUKE UNIVERSITY
- Study coordinator: PENDERGAST, ANN MARIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.