Targeting insulin resistance to improve health outcomes
Combining experiments of man and nature to target human insulin resistance
This study is looking for new ways to help people with insulin resistance, which can lead to serious health issues like type 2 diabetes, by exploring how certain medications change gene activity and finding better treatments that work safely and effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10755312 on NIH RePORTER |
What this research studies
This research investigates new ways to combat insulin resistance, a condition linked to serious chronic diseases like type 2 diabetes, heart attacks, and cancer. It aims to identify novel therapeutic targets by analyzing gene expression changes caused by existing medications, specifically thiazolidinediones (TZDs). The study will utilize advanced methodologies to sift through genetic data from large populations to find effective insulin-sensitizing agents. By leveraging both laboratory experiments and genetic insights, the research seeks to develop safer and more effective treatments for insulin resistance.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with insulin resistance or related chronic conditions such as type 2 diabetes or cardiovascular diseases.
Not a fit: Patients who do not have insulin resistance or related chronic diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively reduce insulin resistance with fewer side effects.
How similar studies have performed: Previous research has shown promise in targeting insulin resistance through genetic insights, but this approach aims to refine and expand upon those findings.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Majithia, Amit — University of California, San Diego
- Study coordinator: Majithia, Amit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.