Targeting inflammation to protect brain cells after a stroke
Multi-pronged Approach to Recalibrating the Inflammatory Cascade in Ischemic Stroke with BET blockade
This study is looking at whether blocking certain proteins that cause inflammation can help protect brain cells after a stroke, and it's for anyone interested in new ways to improve recovery from this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10636852 on NIH RePORTER |
What this research studies
This research investigates how blocking specific proteins involved in inflammation can help reduce cell death in the brain following a stroke. The study focuses on Bromodomain and Extra Terminal Domain (BET) proteins, which play a crucial role in regulating inflammatory responses. By inhibiting these proteins, the researchers aim to enhance the brain's natural anti-inflammatory mechanisms and decrease harmful inflammation that contributes to neuronal damage. The approach involves a combination of molecular techniques to assess the effects of BET blockade on inflammatory gene transcription and cell survival in the ischemic brain.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have experienced an ischemic stroke.
Not a fit: Patients who have not had a stroke or those with hemorrhagic stroke may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect brain cells and improve recovery outcomes for stroke patients.
How similar studies have performed: Previous research has shown promise in targeting inflammatory pathways for neuroprotection, suggesting that this approach could be effective.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Candelario-Jalil, Eduardo Jesus — University of Florida
- Study coordinator: Candelario-Jalil, Eduardo Jesus
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.