Targeting inflammation resolution to improve treatment for inflammatory bowel disease
Official title: Dysregulation of inflammation resolution as therapeutic target for IBD
Funded at University of California Los Angeles · NIH-11063196 · Data updated 2026-11-12
This study is looking at how your body heals inflammation and wounds in the intestines, especially for people with inflammatory bowel disease (IBD) like Crohn's, by exploring how certain immune cells help with the healing process.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | July 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $161,566 |
| NIH project number | 5K01DK133666-03 |
| Project ID | NIH-11063196 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease, particularly those experiencing active inflammation or complications.
✕Less likely to help
Patients with non-inflammatory bowel conditions or those who do not have a diagnosis of inflammatory bowel disease may not benefit from this research.
What this research studies
This research focuses on understanding how the body resolves inflammation and heals intestinal wounds, particularly in patients with inflammatory bowel disease (IBD) like Crohn's disease. The project aims to explore the role of macrophages, a type of immune cell, in clearing dead cells and promoting healing in the intestines. By using innovative human models and advanced analytical techniques, the researchers will investigate the communication between these macrophages and intestinal cells to identify new therapeutic targets. This work seeks to fill knowledge gaps and develop resolution-based therapies that could enhance healing and recovery in IBD patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that promote healing and reduce inflammation in patients with inflammatory bowel disease.
How similar studies have gone: Previous research has shown promise in targeting inflammation resolution for similar conditions, indicating potential for success in this novel approach.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Meriwether, David — University of California Los Angeles
- Study coordinator: Meriwether, David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.