Targeting inflammation resolution to improve treatment for inflammatory bowel disease
Dysregulation of inflammation resolution as therapeutic target for IBD
['FUNDING_CAREER'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11063196
This study is looking at how your body heals inflammation and wounds in the intestines, especially for people with inflammatory bowel disease (IBD) like Crohn's, by exploring how certain immune cells help with the healing process.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11063196 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how the body resolves inflammation and heals intestinal wounds, particularly in patients with inflammatory bowel disease (IBD) like Crohn's disease. The project aims to explore the role of macrophages, a type of immune cell, in clearing dead cells and promoting healing in the intestines. By using innovative human models and advanced analytical techniques, the researchers will investigate the communication between these macrophages and intestinal cells to identify new therapeutic targets. This work seeks to fill knowledge gaps and develop resolution-based therapies that could enhance healing and recovery in IBD patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease, particularly those experiencing active inflammation or complications.
Not a fit: Patients with non-inflammatory bowel conditions or those who do not have a diagnosis of inflammatory bowel disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that promote healing and reduce inflammation in patients with inflammatory bowel disease.
How similar studies have performed: Previous research has shown promise in targeting inflammation resolution for similar conditions, indicating potential for success in this novel approach.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MERIWETHER, DAVID — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: MERIWETHER, DAVID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.