Targeting inflammation in Alzheimer's disease for individuals with Down syndrome
Precision Medicine for Inflammatory Treatment for Alzheimer's Disease in Down Syndrome
This study is looking at how inflammation impacts Alzheimer's disease in people with Down syndrome, aiming to find better ways to treat those who are at higher risk for developing Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-11019654 on NIH RePORTER |
What this research studies
This research investigates how inflammation affects Alzheimer's disease (AD) in individuals with Down syndrome (DS), who are at high risk for developing AD. The study aims to identify specific biological subsets within the DS-AD population to tailor treatments more effectively. By analyzing immune signaling and using advanced techniques like high throughput proteomics on blood samples, researchers hope to find new ways to slow down or alter the progression of AD in these patients. The findings could lead to more personalized treatment strategies for those affected by both conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older with Down syndrome who are at risk for or have been diagnosed with Alzheimer's disease.
Not a fit: Patients who do not have Down syndrome or who are not at risk for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for Alzheimer's disease in individuals with Down syndrome, potentially improving their quality of life.
How similar studies have performed: While there have been few clinical trials specifically targeting Alzheimer's in the Down syndrome population, the approach of using biomarkers and personalized treatment strategies has shown promise in other Alzheimer's research.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Rissman, Robert — University of Southern California
- Study coordinator: Rissman, Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.