Targeting inflammation and mitochondrial issues in Alzheimer's disease
Official title: Reversing Microglial Inflammarafts and Mitochondrial Dysfunction in Alzheimer's Disease
Funded at University of California, San Diego · NIH-10996110 · Data updated 2026-11-12
This study is looking at how brain inflammation affects Alzheimer's disease and is testing a new treatment that uses a special protein to help calm that inflammation, which could help improve brain health for people with Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $691,822 |
| NIH project number | 5R01AG081037-03 |
| Project ID | NIH-10996110 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease, particularly those experiencing significant neuroinflammation.
✕Less likely to help
Patients with other forms of dementia or those without Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates how inflammation in the brain contributes to Alzheimer's disease and explores a potential treatment using a protein that regulates cholesterol and lipid metabolism in microglial cells. The approach involves using a viral vector to deliver this protein directly to the brain, aiming to restore normal function and reduce inflammation in these cells. By understanding the mechanisms behind microglial dysfunction and mitochondrial health, the research seeks to develop a novel therapeutic strategy for Alzheimer's patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or reverse the progression of Alzheimer's disease.
How similar studies have gone: Other research has shown promising results in targeting neuroinflammation and mitochondrial dysfunction in Alzheimer's, suggesting this approach could be effective.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Miller, Yury — University of California, San Diego
- Study coordinator: Miller, Yury
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.