Targeting inflammation and cell death in injured knees
Official title: Imaging and therapeutic targeting of tissue crosstalk in the injured knee
Funded at New York University School of Medicine · NIH-11056006 · Data updated 2026-11-12
This study is looking at how knee injuries can lead to arthritis later on, especially by exploring how inflammation and cell death work together, with the hope of finding new ways to help keep your knees healthy and avoid the need for replacements.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 15, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $711,921 |
| NIH project number | 5R01AR082670-02 |
| Project ID | NIH-11056006 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have suffered an anterior cruciate ligament (ACL) injury and are at risk of developing posttraumatic osteoarthritis.
✕Less likely to help
Patients who have not experienced knee injuries or those with advanced osteoarthritis may not benefit from this research.
What this research studies
This research investigates the mechanisms behind posttraumatic osteoarthritis (PTOA) that can occur after knee injuries, particularly focusing on the roles of inflammation and cell death. The team aims to understand how these two processes interact and contribute to ongoing joint damage. By studying both in laboratory settings and in animal models, they hope to identify new treatment strategies that can effectively restore joint health after injury. The ultimate goal is to develop therapies that can prevent the progression of PTOA, reducing the need for knee replacements in younger patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve joint health and quality of life for individuals with knee injuries.
How similar studies have gone: Other research has shown promise in targeting inflammation and apoptosis in joint injuries, suggesting that this approach could lead to meaningful advancements in treatment.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Ruiz Garzon, Maria Amparo — New York University School of Medicine
- Study coordinator: Ruiz Garzon, Maria Amparo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.