Targeting inflammation and bone loss in gum disease
Inhibiting inflammation and bone erosion in periodontal disease by targeting cell endogenous negative signaling
This study is looking at how certain signals in the body can lead to inflammation and bone loss in gum disease, which affects many adults over 30, with the goal of finding new ways to treat it and help keep your gums and teeth healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-10559645 on NIH RePORTER |
What this research studies
This research investigates how certain cell signaling processes contribute to chronic inflammation and bone loss in periodontal disease, a common condition affecting many adults over 30. By understanding these mechanisms, the study aims to identify new therapeutic strategies to treat periodontal disease effectively. The research involves examining the effects of specific signaling pathways on periodontal tissues and their functional capacity, with a focus on reducing inflammation and preserving bone health. Patients may benefit from potential new treatments that arise from this understanding.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over the age of 30 who are experiencing periodontal disease or related bone loss.
Not a fit: Patients who do not have periodontal disease or are under the age of 30 may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that prevent tooth loss and improve overall oral health for patients with periodontal disease.
How similar studies have performed: Previous research has shown promise in targeting cell signaling pathways to manage inflammation and bone loss, indicating that this approach may yield successful outcomes.
Where this research is happening
New Orleans, United States
- Tulane University of Louisiana — New Orleans, United States (Active)
Researchers
- Principal investigator: Li, Yi-Ping — Tulane University of Louisiana
- Study coordinator: Li, Yi-Ping
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.