Targeting immune cells in brain tumors to improve treatment outcomes
Harnessing Tumor Associated Macrophages in Glioblastoma
['FUNDING_CAREER'] · MAYO CLINIC ROCHESTER · NIH-11018519
This study is exploring how to change certain immune cells in the brain that help glioblastoma grow, so they can instead help your body fight the cancer, with the hope of finding better treatment options for patients like you.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11018519 on ClinicalTrials.gov |
What this research studies
This research investigates how tumor-associated macrophages (TAMs) in glioblastoma, a highly aggressive brain cancer, can be manipulated to enhance the body's immune response against the tumor. By understanding the molecular mechanisms that control the behavior of these immune cells, the research aims to shift them from a state that supports tumor growth to one that promotes anti-tumor immunity. The approach involves targeting specific signaling pathways to potentially improve the effectiveness of existing therapies. Patients may benefit from new treatment strategies that could lead to better outcomes in managing glioblastoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with glioblastoma who are seeking new treatment options.
Not a fit: Patients with non-glioblastoma brain tumors or those who are not eligible for experimental therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that significantly improve survival rates and quality of life for glioblastoma patients.
How similar studies have performed: Previous research has shown promise in targeting immune cells in other cancers, suggesting that this approach may also be effective in glioblastoma.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HOFSTATTER AZAMBUJA, JULIANA — MAYO CLINIC ROCHESTER
- Study coordinator: HOFSTATTER AZAMBUJA, JULIANA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.