Targeting immune cell activation to reduce airway narrowing
Targeting pathologic macrophage activation through inhibition of MyD88 to attenuate laryngotracheal stenosis
This study is looking into how certain immune cells might cause narrowing of the airway in people who have had long-term intubation, with the hope of finding new treatments to help manage this condition better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11034122 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind laryngotracheal stenosis (LTS), a condition that causes narrowing of the airway due to prolonged intubation. It focuses on understanding how certain immune cells, particularly macrophages, contribute to the development of this condition. By using advanced techniques like single cell RNA sequencing, the research aims to identify specific pathways that can be targeted to inhibit harmful immune responses. The ultimate goal is to develop new medical therapies that can improve the management of LTS and enhance patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced prolonged intubation and are suffering from laryngotracheal stenosis.
Not a fit: Patients who do not have laryngotracheal stenosis or have not undergone intubation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that alleviate airway narrowing and improve breathing and communication for patients with laryngotracheal stenosis.
How similar studies have performed: Previous research has shown promising results in targeting immune responses in similar conditions, indicating potential for success in this approach.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Motz, Kevin — Johns Hopkins University
- Study coordinator: Motz, Kevin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.