Targeting immune cell activation to reduce airway narrowing
Official title: Targeting pathologic macrophage activation through inhibition of MyD88 to attenuate laryngotracheal stenosis
Funded at Johns Hopkins University · NIH-11034122 · Data updated 2026-11-12
This study is looking into how certain immune cells might cause narrowing of the airway in people who have had long-term intubation, with the hope of finding new treatments to help manage this condition better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | March 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $197,554 |
| NIH project number | 5K23DC020988-03 |
| Project ID | NIH-11034122 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced prolonged intubation and are suffering from laryngotracheal stenosis.
✕Less likely to help
Patients who do not have laryngotracheal stenosis or have not undergone intubation may not benefit from this research.
What this research studies
This research investigates the mechanisms behind laryngotracheal stenosis (LTS), a condition that causes narrowing of the airway due to prolonged intubation. It focuses on understanding how certain immune cells, particularly macrophages, contribute to the development of this condition. By using advanced techniques like single cell RNA sequencing, the research aims to identify specific pathways that can be targeted to inhibit harmful immune responses. The ultimate goal is to develop new medical therapies that can improve the management of LTS and enhance patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that alleviate airway narrowing and improve breathing and communication for patients with laryngotracheal stenosis.
How similar studies have gone: Previous research has shown promising results in targeting immune responses in similar conditions, indicating potential for success in this approach.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Motz, Kevin — Johns Hopkins University
- Study coordinator: Motz, Kevin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.