Targeting how androgen receptors work in prostate cancer
Targeting androgen receptor nuclear localization in prostate cancer
This study is looking at how certain receptors in prostate cancer cells work and testing new small molecules that might help slow down the cancer and make current treatments work better, especially for patients whose cancer isn't responding to standard therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11093316 on NIH RePORTER |
What this research studies
This research investigates the role of androgen receptors in prostate cancer, particularly in cases that are resistant to standard treatments. The team has developed small molecules that can inhibit the nuclear localization of these receptors, which is crucial for their function. By targeting this mechanism, the research aims to slow the progression of prostate cancer and enhance the effectiveness of existing therapies. Patients may benefit from new treatment options that could improve outcomes for those with advanced prostate cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are American men diagnosed with castration-resistant prostate cancer.
Not a fit: Patients with early-stage prostate cancer or those who do not have androgen receptor involvement may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for patients with advanced prostate cancer.
How similar studies have performed: Other research has shown promise in targeting androgen receptors, but this approach using nuclear localization is relatively novel.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Wang, Zhou — University of Pittsburgh at Pittsburgh
- Study coordinator: Wang, Zhou
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.