Targeting HIV reservoirs to reduce inflammation in patients
Official title: Understanding and targeting the HIV-expressing reservoir to reduce immune activation
Funded at University of California, San Francisco · NIH-11052612 · Data updated 2026-11-12
This study is looking at how HIV can still impact the immune system in people who are taking medication to manage the virus, and it aims to find out what parts of the virus might be causing ongoing inflammation and health problems, so we can improve care for those living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | March 8, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $795,083 |
| NIH project number | 5R01AI183666-02 |
| Project ID | NIH-11052612 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy and have achieved viral suppression.
✕Less likely to help
Patients who are not living with HIV or those who are not on antiretroviral therapy may not benefit from this research.
What this research studies
This research investigates how HIV continues to affect the immune system even in patients receiving antiretroviral therapy (ART). It aims to identify the specific viral products that contribute to ongoing inflammation and immune activation in people living with HIV. By analyzing blood and gut samples from patients on ART, the study will explore the relationship between low-level HIV expression and inflammation. The goal is to better understand the mechanisms behind persistent health issues in these patients and to develop targeted interventions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that reduce inflammation and enhance the overall health of people living with HIV.
How similar studies have gone: Previous research has shown promise in targeting HIV reservoirs and understanding immune activation, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Yukl, Steven a — University of California, San Francisco
- Study coordinator: Yukl, Steven a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.