Targeting HIV reservoirs to improve treatment outcomes
Targeted interventions to reduce or eliminate the SIV reservoir in a novel model of elite control
This study is exploring new ways to find and tackle the hidden spots where HIV can hide in the body, which could help create better treatments for people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11061890 on NIH RePORTER |
What this research studies
This research investigates innovative methods to reduce or eliminate the reservoirs of HIV in the body, which are responsible for the virus's persistence despite treatment. By using a unique animal model, the study aims to understand the mechanisms that allow the virus to hide and evade the immune system. The approach focuses on identifying vulnerabilities in these reservoirs and developing targeted interventions that could lead to more effective treatments for HIV. Patients may benefit from insights gained that could lead to breakthroughs in HIV therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy and have a history of viral persistence.
Not a fit: Patients who are newly diagnosed with HIV or those who do not have a history of viral reservoirs may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments that eliminate HIV reservoirs, potentially allowing patients to stop antiretroviral therapy without viral rebound.
How similar studies have performed: While there has been significant research into HIV treatment, this specific approach using a novel animal model to target viral reservoirs is relatively untested and could provide new insights.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Hoxie, James a — University of Pennsylvania
- Study coordinator: Hoxie, James a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.