Targeting HIV persistence through immune response
Investigating antigen-driven clonal proliferation to target HIV-1 persistence
['FUNDING_OTHER'] · JOHNS HOPKINS UNIVERSITY · NIH-10918343
This study is looking at how the immune system's reaction to HIV affects the virus's ability to stay in the body, with the goal of finding new ways to help people with HIV live without needing medication.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10918343 on ClinicalTrials.gov |
What this research studies
This research investigates how the immune system's response to HIV can influence the persistence of the virus in the body. It focuses on understanding the role of chronic antigens in the clonal expansion of infected CD4+ T cells, which are a major contributor to the HIV reservoir. By exploring how these immune responses affect the behavior of HIV-infected cells, the research aims to develop new strategies to reduce or eliminate this reservoir, potentially leading to a drug-free remission for patients. The study will involve various methodologies to assess the impact of antigens on HIV latency and the factors driving clonal expansion.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy and are interested in potential new treatment options.
Not a fit: Patients who are not living with HIV or those who are not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that allow people living with HIV to achieve long-term remission without the need for continuous antiretroviral therapy.
How similar studies have performed: Previous research has shown promise in targeting HIV reservoirs, suggesting that this approach could lead to significant advancements in HIV treatment.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SIMONETTI, FRANCESCO ROBERTO — JOHNS HOPKINS UNIVERSITY
- Study coordinator: SIMONETTI, FRANCESCO ROBERTO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus