Targeting HIF protein partners that help tumors grow
Full Project 1: Structural, chemical, and cellular probing of a new anticancer target: HIF-coactivator complexes
This research tries blocking HIF and its partner proteins to slow tumors such as certain kidney cancers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11194508 on NIH RePORTER |
What this research studies
Researchers will use high-resolution structural methods (like cryo-EM), biochemical assays, and cell-based tests to map how ARNT/HIF proteins bind their coactivators. They will screen and optimize small molecules that can disrupt those protein-protein interactions. Promising compounds will be characterized for how they change cellular behavior relevant to tumor growth. The work combines expertise from multiple labs and builds on preliminary structural and inhibitor data.
Who could benefit from this research
Good fit: People with tumors known to be driven by HIF overexpression—for example some kidney cancers—would be most relevant for future trials or sample donations.
Not a fit: Patients whose cancers are not driven by HIF pathways or people without cancer are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could lead to new drugs that slow or stop cancers driven by HIF activity.
How similar studies have performed: Early lab studies and structural data have shown promising leads and moderate-potency inhibitors, but clinical benefit in patients has not yet been demonstrated.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Tan, Derek S — Sloan-Kettering Inst Can Research
- Study coordinator: Tan, Derek S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.