Targeting hidden cancer cells with advanced imaging and therapy techniques
Multiplexed and dynamically targeted photoimmunotherapy of heterogeneous, chemoresistant micrometastases guided by online in vivo optical imaging of cell-surface biomarkers
This study is exploring a new way to help people with advanced ovarian cancer by using a tiny microscope to find hidden tumor cells that regular scans might miss, and pairing this with special treatments that can better target and fight these tough-to-treat tumors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeastern University NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10830993 on NIH RePORTER |
What this research studies
This research focuses on improving treatment for metastatic epithelial ovarian cancer, which often has hidden tumor cells that traditional imaging cannot detect. By using a miniaturized microscope for advanced imaging, the study aims to visualize these microscopic tumor deposits in real-time. It combines this imaging with targeted therapies that activate upon binding to cancer cells, allowing for more effective treatment of drug-resistant tumors. The approach is designed to address the challenges posed by tumor heterogeneity and improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with metastatic epithelial ovarian cancer, particularly those with drug-resistant tumors.
Not a fit: Patients with early-stage ovarian cancer or those without metastatic disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with hard-to-detect metastatic ovarian cancer.
How similar studies have performed: Other research has shown promise in using advanced imaging and targeted therapies for cancer treatment, indicating potential success for this novel approach.
Where this research is happening
Boston, United States
- Northeastern University — Boston, United States (Active)
Researchers
- Principal investigator: Spring, Bryan Quilty — Northeastern University
- Study coordinator: Spring, Bryan Quilty
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.