Targeting heart failure in people with HIV
Avoiding (Heart) Failure: Physiologic-Based Targeting of the RAAS to Treat Subclinical HFpEF among PWH
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10750990
This study is looking at how heart failure affects people living with HIV, especially focusing on how certain hormones might be involved in heart problems, and it aims to find new ways to help improve heart health for these individuals.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10750990 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms of heart failure with preserved ejection fraction (HFpEF) in individuals living with HIV, focusing on the role of the renin-angiotensin-aldosterone system (RAAS). The study aims to understand how myocardial inflammation and fibrosis contribute to heart dysfunction in this population. By conducting rigorous hormonal testing, the researchers will explore the relationship between RAAS activation and heart health, with the goal of identifying potential therapeutic targets. Patients may undergo assessments such as echocardiograms to evaluate heart function and structure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are asymptomatic but may show early signs of heart dysfunction.
Not a fit: Patients who do not have HIV or those with advanced heart failure symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively reduce heart failure risk and improve heart health in people living with HIV.
How similar studies have performed: Previous research has indicated that targeting the RAAS may be beneficial in managing heart conditions, suggesting potential for success in this novel approach.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SRINIVASA, SUMAN — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: SRINIVASA, SUMAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: chronic disorder